Sodium Hydroxide → Ethyl (3S)-piperidine-3-carboxylate

HRID 272094

Reaktionsgleichung

Reaktionsgleichung von HRID 272094
C(O)(=O)[C@H]([C@@H](C(O)=O)O)O.[NH:11]1[CH2:16][CH2:15][CH2:14][C@H:13]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:12]1.[OH-].[Na+]>>[NH:11]1[CH2:16][CH2:15][CH2:14][C@H:13]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:12]1

Komponenten

3

Edukt 2

HCID 14798Sodium HydroxideHCID 14183617Ethyl (S)-3-Piperidinecarboxylate D-Tartrate

Produkt 1

HCID 187784Ethyl (3S)-piperidine-3-carboxylateAusbeute 112,8 %

Versuchsvorschrift

To 13.0 g of ethyl (3S)-3-piperidinecarboxylate D(−)-tartarate which was synthesized following the method of P. Magnus, et al. [J. Org. Chem. Vol. 56, 1166-1170 (1991)], 3N aqueous sodium hydroxide solution was added to render the former basic, followed by extraction with chloroform and drying over anhydrous magnesium sulfate. Distilling the solvent off under reduced pressure, 7.50 g of the title compound was obtained.

Aufarbeitung

  1. extractionfollowed by extraction with chloroform
  2. dry with materialdrying over anhydrous magnesium sulfate
  3. distillationDistilling the solvent off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-96b0cc3b998343d5bc036a7bcedf6292
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07452908B2

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