1,2,3,6-Tetrahydropyridine → HCID 178501988, Verbindung

HRID 27227

Reaktionsgleichung

Reaktionsgleichung von HRID 27227
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]([O:11][CH3:12])=[O:10])[N+:5]([O-:13])=[C:4]([NH:14][C:15]([O:17][CH3:18])=[O:16])[CH:3]=1.[NH:19]1[CH2:24][CH2:23][CH:22]=[CH:21][CH2:20]1>C(Cl)Cl>[N:19]1([C:2]2[N:7]=[C:6]([NH:8][C:9]([O:11][CH3:12])=[O:10])[N+:5]([O-:13])=[C:4]([NH:14][C:15]([O:17][CH3:18])=[O:16])[CH:3]=2)[CH2:20][CH:21]=[CH:22][CH2:23][CH2:24]1

Komponenten

4

Edukt 2

HCID 127501,2,3,6-TetrahydropyridineHCID 178501976HCID 178501976, Verbindung

Produkt 1

HCID 178501988HCID 178501988, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

A suspension of 10 g. of dimethyl 6-chloro-2,4-pyrimidinedicarbamate-3-oxide in 40 ml. of methylene chloride is treated with 20 ml. of 1,2,5,6-tetrahydropyridine and stirred at room temperature under an argon atmosphere for 16 hours. The precipitate formed is filtered off and recrystallized from a mixture of methylene chloride and methanol, there being obtained pure dimethyl 6-[3,6-dihydro-1(2H)-pyridyl]-2,4-pyrimidinedicarbamate-3-oxide having a melting point of 203° C.

Aufarbeitung

  1. additionA suspension of 10 g
  2. customThe precipitate formed
  3. filtrationis filtered off
  4. customrecrystallized from a mixture of methylene chloride and methanol, there

Quellen und Nachweise

ORD-Eintrag
ord-12bf4e584d814a6e9a291da96b9af07e
Quelldatensatz
uspto-grants-1980_09
Patentnummer
US04220772

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