Chloroform → (-)-5,6-Dimethoxy-2-[2,2,4,6,7-pentamethyl-3-(4-ethylphenyl)-2,3-dihydro-1-benzofuran-5-yl]isoindoline hydrochloride

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Chloroform	HCID 6212	—
Edukt	5,6-Dimethoxy-2-[2,2,4,6,7-pentamethyl-3-(4-methylphenyl)-2,3-dihydro-1-benzofuran-5-yl]isoindoline	HCID 9911986	—
Produkt	(-)-5,6-Dimethoxy-2-[2,2,4,6,7-pentamethyl-3-(4-ethylphenyl)-2,3-dihydro-1-benzofuran-5-yl]isoindoline hydrochloride	HCID 21961328	61%

Reaktionsschritte

By using (−)-5,6-dimethoxy-2-[2,2,4,6,7-pentamethyl-3-(4-methylphenyl)-2,3-dihydro-1-benzofuran-5-yl]isoindoline, the title compound was synthesized according to Example 19a. Yield: 61%. Melting point: 173-175° C. [α]D=−44.4° (c=0.501, chloroform)

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07456162B2
Quelldatensatz	uspto-grants-2008_11
ORD ID	ord-1b8d48d5c0c14b7e81cc92a704522b31
Quellennotiz	uspto-grants-2008_11