Methyl iodide → HCID 45119279, Verbindung

HRID 272536

Reaktionsgleichung

Reaktionsgleichung von HRID 272536
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:4][N:3]=1.[OH-].[K+].[CH3:14]I>CC(C)=O>[Cl:1][C:2]1[CH:7]=[C:6]([N:8]([CH3:14])[C:9](=[O:11])[CH3:10])[CH:5]=[CH:4][N:3]=1

Komponenten

5

Edukt 3

HCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 2049955N-(2-chloropyridin-4-yl)acetamide

Produkt 1

HCID 45119279HCID 45119279, VerbindungAusbeute 600,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A mixture of 10 g (59 mmol) N-(2-chloropyridin-4-yl)acetamide (commercially available), 9.8 g (17.6 mmol) pulverized KOH and 4.1 ml (6.4 mmol) methyl iodide in 60 ml acetone was stirred at room temperature for 2 h. After evaporation of all volatiles the residue was taken up in water and extracted with ethyl acetate. The combined organic layers were dried with MgSO4 and evaporated to yield 7.1 g (66%) of the title compound as off-white solid. MS: (m/e): 345.2 (MH+).

Aufarbeitung

  1. customAfter evaporation of all volatiles the residue
  2. extractionextracted with ethyl acetate
  3. dry with materialThe combined organic layers were dried with MgSO4
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-52ac5c96003c4f889411ab8a90617c22
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07456175B2

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