Hydrochloric Acid → 4-Vinylsulfonyl-morpholine

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

5H-Indolo[2,1-a][2]benzazepine-10-carboxamide, 13-cyclohexyl-N-[(dimethylamino)sulfonyl]-6,7-dihydro-3-methoxy-6-(4-morpholinylsulfonyl)-. To a solution of 5H-indolo[2,1-a][2]benzazepine-10-carboxylic acid, 13-cyclohexyl-6,7-dihydro-3-methoxy-6-(4-morpholinylsulfonyl)-(45 mg, 0.084 mmol) in CH2Cl2 (1.0 mL) was added 2M oxalyl chloride (0.20 mL) in CH2Cl2. This solution was stirred at 22° C. for 2 hr and concentrated under reduced pressure. The resulting yellow oil was redissolved in CH2Cl2 (1.0 mL); BEMP (0.10 mL, 0.33 mmol) and dimethylsulfamide (42 mg, 0.33 mmol) were added. The resulting mixture was allowed to stir at 22° C. for 6 hr. 1M HCl (15 mL) was added and the aqueous layer was extracted with CHCl3 (2×20 mL). The organic phase was concentrated under reduced pressure. This oil was purified by reverse-phase prep HPLC to afford the title compound (34 mg, 64%) as a yellow paste. MS m/z 645 (MH+). Two rotomers present in NMR. 1H NMR (300 MHz, CDCl3) δ ppm 1.26 (m, 1H), 1.32-1.49 (m, 2H), 1.64 (m, 1H), 1.78 (m, 2H), 1.88-2.10 (m, 4H), 2.89 (m, 1H), 2.97-3.15 (m, 9H), 3.36 (m, 2.6H), 3.45 (m, 1.4H), 3.66-3.81 (m, 4H), 3.92 (d, 3H), 3.96 (m, 0.65H), 4.07 (m, 0.35H), 4.72 (m, 0.35H), 4.97 (d, J=15 Hz, 0.65H), 6.92 (m, 0.65H), 6.97 (m, 1.35H), 7.33-7.47 (m, 2H), 7.87 (m, 1H), 7.99 (m, 1H), 8.55 (broad s, 1H).

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