Formamidine acetate → 6,7,8,9-Tetrahydro-5H-5,9-methanopyrimido[4,5-d]azepin-2-amine

HRID 272621

Reaktionsgleichung

Reaktionsgleichung von HRID 272621
C([N:8]1[CH2:18][CH:17]2[CH2:19][CH:10]([C:11]3[CH:12]=[N:13][C:14](C)=[N:15][C:16]=32)[CH2:9]1)C1C=CC=CC=1.C(O)(=O)C.C(N)=[NH:26]>>[CH:17]12[CH2:19][CH:10]([CH2:9][NH:8][CH2:18]1)[C:11]1[CH:12]=[N:13][C:14]([NH2:26])=[N:15][C:16]2=1

Komponenten

3

Edukt 2

HCID 160693Formamidine acetateHCID 5983782510-Benzyl-4-methyl-3,5,10-triaza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene

Produkt 1

HCID 688055646,7,8,9-Tetrahydro-5H-5,9-methanopyrimido[4,5-d]azepin-2-amine

Versuchsvorschrift

Following the method described in Example 13, 10-benzyl-4-methyl-3,5,10-triaza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene and formamidine acetate were converted to the title compound in 18% overall yield. APCl MS m/z 177.1 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-c1d4b54bac994441950d571e40c8920c
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07456177B2

Verknüpfte Notizen

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