Triethylamine → [1-(5-Bromo-2-chloro-pyrimidin-4-ylamino)-cyclopentyl]-methanol

HRID 272637

Reaktionsgleichung

Reaktionsgleichung von HRID 272637
[Br:1][C:2]1[C:3](Cl)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.C(N(CC)CC)C.[NH2:17][C:18]1([CH2:23][OH:24])[CH2:22][CH2:21][CH2:20][CH2:19]1>C(#N)C>[Br:1][C:2]1[C:3]([NH:17][C:18]2([CH2:23][OH:24])[CH2:22][CH2:21][CH2:20][CH2:19]2)=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 663071-AminocyclopentanemethanolHCID 2899735-Bromo-2,4-dichloropyrimidine

Produkt 1

HCID 58890910[1-(5-Bromo-2-chloro-pyrimidin-4-ylamino)-cyclopentyl]-methanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

An ice-cooled solution of 2.28 g (10.0 mmol) of 5-Bromo-2,4-dichloropyrimidine and 1.7 ml (12.0 mmol) of triethylamine in 10 ml of acetonitrile is mixed with 1.38 g (12.0 mmol) (1-amino-cyclopentyl)-methanol. After 16 hours at room temperature the batch is filtrated to remove the solid precipitate. The precipitate is dried. 1.48 g (4.8 mmol, corresponding to 48% of theory) of the product is obtained.

Aufarbeitung

  1. filtrationAfter 16 hours at room temperature the batch is filtrated
  2. customto remove the solid precipitate
  3. customThe precipitate is dried
  4. custom1.48 g (4.8 mmol, corresponding to 48% of theory) of the product is obtained

Quellen und Nachweise

ORD-Eintrag
ord-4f89754d63b247c6b3faa1cdccff09da
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07456191B2

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