1-Benzylpiperidin-4-ol → 1-benzyl-4-piperidyl N-(2-biphenylyl)carbamate

HRID 272792

Reaktionsgleichung

Reaktionsgleichung von HRID 272792
[C:1]1([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:2]([N:7]=[C:8]=[O:9])=[CH:3][CH:4]=[CH:5][CH:6]=1.[CH2:16]([N:23]1[CH2:28][CH2:27][CH:26]([OH:29])[CH2:25][CH2:24]1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(#N)C>[C:1]1([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][C:8](=[O:9])[O:29][CH:26]1[CH2:27][CH2:28][N:23]([CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:24][CH2:25]1

Komponenten

4

Edukt 2

HCID 784611-Benzylpiperidin-4-olHCID 2222801-Isocyanato-2-phenylbenzene

Produkt 1

HCID 105003691-benzyl-4-piperidyl N-(2-biphenylyl)carbamate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

In a 50 ml sealed tube was added 2-biphenylylisocyanate (8 g, 41 mmol) in anhydrous acetonitrile (40 mL). To this solution was added N-benzyl-4-piperidinol (9.8 g, 51.25 mmol) and the tube was partially immersed in a silicon oil bath and heated to 85° C. After 16 h, the reaction mixture was cooled and concentrated in vacuo to give a 1-benzyl-4-piperidyl N-(2-biphenylyl)carbamate which was used in the next step without further purification.

Aufarbeitung

  1. customIn a 50 ml sealed tube
  2. customthe tube was partially immersed in a silicon oil bath
  3. temperaturethe reaction mixture was cooled
  4. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-dfba0cfa044b47189426397db92aff74
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07456203B2

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