9-Ethylenedioxy-15-keto-19-methyl-prost-13,18-dienoic acid, methyl ester → 9-Ethylenedioxy-15-keto-19-methyl-prost-18-enoic acid, methyl ester
Reaktionsgleichung
[CH2:1]1[CH2:19][O:18][CH:17]2[CH:3]([C@@H:4]([C@@H:15]([CH:20]=[CH:21][C:22](=[O:29])[CH2:23][CH2:24][CH:25]=[C:26]([CH3:28])[CH3:27])[CH2:16]2)[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])[O:2]1>C(O)C.[Ni]>[CH2:1]1[CH2:19][O:18][CH:17]2[CH:3]([C@@H:4]([C@@H:15]([CH2:20][CH2:21][C:22](=[O:29])[CH2:23][CH2:24][CH:25]=[C:26]([CH3:27])[CH3:28])[CH2:16]2)[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])[O:2]1Komponenten
4
Versuchsvorschrift
To the solution of 4.4 g of 9-ethylenedioxy-15-keto-19-methyl-prost-13,18-dienoic acid, methyl ester, in ethanol (60 ml.) are added 0.8 g of Raney-nickel washed with ethanol and the mixture is hydrogenated at room temperature under pressure. After absorption of the theoretical quantity of hydrogen the catalyzer is separated by filtration and the solvent evaporated in vacuo, to yield 3.9 g of 9-ethylenedioxy-15-keto-19-methyl-prost-18-enoic acid, methyl ester.