Thionyl Chloride → HCID 68576193, Verbindung

HRID 272994Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 272994
[CH:1]([N:14]1[CH2:17][CH:16]([CH2:18]O)[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:22])=O>ClCCl>[ClH:22].[CH:1]([N:14]1[CH2:17][CH:16]([CH2:18][Cl:22])[CH2:15]1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 2758715(1-Benzhydrylazetidin-3-yl)methanol

Produkt 1

HCID 68576193HCID 68576193, VerbindungAusbeute 168,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Reaktionsbedingungen

Temperatur
2.5 °C

Versuchsvorschrift

(1-Benzhydryl-azetidin-3-yl)-methanol (3.07 g, 12.1 mmol) was dissolved in dichloromethane (60 ml). The reaction was cooled to 0-5° C. and thionyl chloride (1.07 ml, 14.6 mmol) was added slowly. The reaction was allowed to warm to room temperature and stirred for 18 hours. The reaction was concentrated in vacuo and azeotroped with toluene (3×20 ml) to give the title compound (3.8 g, 100%) as a pale brown solid.

Aufarbeitung

  1. temperatureto warm to room temperature
  2. concentrationThe reaction was concentrated in vacuo
  3. customazeotroped with toluene (3×20 ml)

Quellen und Nachweise

ORD-Eintrag
ord-487dd085125e4edcbd1de025078c0b97
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07456164B2

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