4-Formylbenzoic acid → 4-(4-Methyl-1-piperazinylmethyl)benzoic acid

HRID 273296Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 273296
[CH:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=1)=O.[CH3:12][N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1.[H][H]>CO.[Pt]>[CH3:12][N:13]1[CH2:18][CH2:17][N:16]([CH2:1][C:3]2[CH:11]=[CH:10][C:6]([C:7]([OH:9])=[O:8])=[CH:5][CH:4]=2)[CH2:15][CH2:14]1

Komponenten

6

Edukt 3

HCID 120884-Formylbenzoic acidHCID 531671-MethylpiperazineHCID 178418361HCID 178418361, Verbindung2×

Produkt 1

HCID 47697824-(4-Methyl-1-piperazinylmethyl)benzoic acidAusbeute 70 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23939PlatinumKatalysatorHCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A suspension of 4-formyl-benzoic acid (10.0 g, 67 mmol) in methanol (100 ml) is treated sequentially with 1-methylpiperazine (7.3 g, 73 mmol) and platinum (5%) on sulfided carbon (1 g). The resulting suspension is then heated at 80° C. and is subjected to a pressure of 5 bar of hydrogen for a period of 20 hrs until the hydrogen uptake is complete. The reaction mixture is cooled to room temperature and filtrated over a pad of Celite. Water (20 ml) is used to rinse the reactor and dissolve the fraction of 4-(4-methyl-piperazin-1-ylmethyl)-benzoic acid that crystallizes on the walls during the cooling of the reaction mixture. The resulting aqueous solution is filtrated over the pad of Celite employed previously. The combined filtrates are concentrated in vacuo and crystallized In EtOH/H2O 9:1 v/v to give 10.9 g (70%) of 4-(4-methyl-piperazin-1-ylmethyl)-benzoic acid as colorless crystals.

Aufarbeitung

  1. temperatureThe reaction mixture is cooled to room temperature
  2. filtrationfiltrated over a pad of Celite
  3. washto rinse the reactor
  4. dissolutiondissolve the fraction of 4-(4-methyl-piperazin-1-ylmethyl)-benzoic acid
  5. customthat crystallizes on the walls during the
  6. temperaturecooling of the reaction mixture
  7. filtrationThe resulting aqueous solution is filtrated over the pad of Celite
  8. concentrationThe combined filtrates are concentrated in vacuo
  9. customcrystallized In EtOH/H2O 9:1 v/v

Quellen und Nachweise

ORD-Eintrag
ord-7e3a09b82a1d4349b98c983a793ee551
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07456283B2

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