Dimethylcarbamoyl Chloride → 4-Dimethylcarbamoyloxy-2,5-dimethylphenyl methyl sulphide

HRID 27335Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 27335
[CH3:1][C:2]1[CH:7]=[C:6]([S:8][CH3:9])[C:5]([CH3:10])=[CH:4][C:3]=1[OH:11].[CH3:12][N:13]([CH3:17])[C:14](Cl)=[O:15]>N1C=CC=CC=1>[CH3:9][S:8][C:6]1[CH:7]=[C:2]([CH3:1])[C:3]([O:11][C:14](=[O:15])[N:13]([CH3:17])[CH3:12])=[CH:4][C:5]=1[CH3:10]

Komponenten

4

Edukt 2

HCID 6598Dimethylcarbamoyl ChlorideHCID 12889671HCID 12889671, Verbindung

Produkt 1

HCID 128896874-Dimethylcarbamoyloxy-2,5-dimethylphenyl methyl sulphide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 25.2 g 2,5-dimethyl-4-(methylthio)phenol and 20.3 ml dimethylcarbamoyl chloride in 70 ml dry pyridine was heated for 24 hours at 100° C. Addition to excess of ice-cold dilute hydrochloric acid gave an oil. The oil product was extracted into ether and washed three times with cold dilute sodium hydroxide and once with water, dried, and the ether removed by evaporation to give 4-dimethylcarbamoyloxy-2,5-dimethylphenyl methyl sulphide, boiling point 146° C. at 0.6 mm to 150° C. to 0.9 mm.

Aufarbeitung

  1. additionAddition to excess of ice-cold dilute hydrochloric acid
  2. customgave an oil
  3. extractionThe oil product was extracted into ether
  4. washwashed three times with cold dilute sodium hydroxide
  5. dry with materialonce with water, dried
  6. customthe ether removed by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-7230bcee4b094bab8a059f5deb486c74
Quelldatensatz
uspto-grants-1980_09
Patentnummer
US04221582

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