Potassium Carbonate → N-(thiazol-4-yl)methyl-2-ethyl-6-methylaniline

HRID 27339

Reaktionsgleichung

Reaktionsgleichung von HRID 27339
Cl[CH2:2][C:3]1[N:4]=[CH:5][S:6][CH:7]=1.[CH2:8]([C:10]1[CH:16]=[CH:15][CH:14]=[C:13]([CH3:17])[C:11]=1[NH2:12])[CH3:9].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[S:6]1[CH:7]=[C:3]([CH2:2][NH:12][C:11]2[C:13]([CH3:17])=[CH:14][CH:15]=[CH:16][C:10]=2[CH2:8][CH3:9])[N:4]=[CH:5]1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 324852-Ethyl-6-methylanilineHCID 27632904-(Chloromethyl)-1,3-thiazole

Produkt 1

HCID 20534534N-(thiazol-4-yl)methyl-2-ethyl-6-methylanilineAusbeute 39,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

In 200 ml dry dimethylformamide was added 10.2 g 4-chloromethylthiazole, 10.26 g 2-ethyl-6-methylaniline and 10.54 g of potassium carbonate. The mixture was stirred at 100° C. for 3 days and filtered. The filtrate was stripped, dissolved in methylene chloride, washed with water, dried and stripped again. The crude product was chromatographed with methylene chloride through a 200-g silica-gel column to give 7 g of product.

Aufarbeitung

  1. filtrationfiltered
  2. dissolutiondissolved in methylene chloride
  3. washwashed with water
  4. customdried
  5. customThe crude product was chromatographed with methylene chloride through a 200-g silica-gel column

Quellen und Nachweise

ORD-Eintrag
ord-b9e27a171eb14d4e9634988a95ba4bfe
Quelldatensatz
uspto-grants-1980_09
Patentnummer
US04221584

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