4'-Fluoro-2'-hydroxyacetophenone → 4-Fluorobenzaldehyde

HRID 273484

Reaktionsgleichung

Reaktionsgleichung von HRID 273484
O[C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:11])C>CO>[F:8][C:6]1[CH:7]=[CH:2][C:3]([CH:9]=[O:11])=[CH:4][CH:5]=1

Komponenten

3

Edukt 1

HCID 27373264'-Fluoro-2'-hydroxyacetophenone

Produkt 1

HCID 680234-FluorobenzaldehydeAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a mixture of (2-hydroxy-4-fluoro phenyl)-1-ethanone (3 g, 19.7 mmol) obtained in Preparation 5, and 4-fluorobenzaldehyde (4.37 g, 19.7 mmol) in methanol was slowly added sodium hydroxide solution at 0° C., under N2 atm. The reaction mixture was allowed to stir for 10 hours at 0-10° C. Water (100 mL) was added to it followed by 6 N HCl (15 mL). Solid separated was filtered off and dried under vacuum to afford 3 g (41%) of the title compound as a yellow solid.

Quellen und Nachweise

ORD-Eintrag
ord-882c3530be6e4406ac9e528337db66ac
Quelldatensatz
uspto-grants-2008_11
Patentnummer
US07456288B2

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