Diisobutylamine → {4-[Bis(2-methylpropyl)amino]-3-nitrophenyl}(phenyl)methanone

HRID 27377

Reaktionsgleichung

Reaktionsgleichung von HRID 27377
[N+:1]([C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][C:17]=1Cl)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8])([O-:3])=[O:2].[CH2:19]([NH:23][CH2:24][CH:25]([CH3:27])[CH3:26])[CH:20]([CH3:22])[CH3:21]>C(O)C>[N+:1]([C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][C:17]=1[N:23]([CH2:24][CH:25]([CH3:27])[CH3:26])[CH2:19][CH:20]([CH3:22])[CH3:21])[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8])([O-:3])=[O:2]

Komponenten

4

Edukt 2

HCID 8085DiisobutylamineHCID 417434-Chloro-3-nitrobenzophenone

Produkt 1

HCID 23342780{4-[Bis(2-methylpropyl)amino]-3-nitrophenyl}(phenyl)methanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Versuchsvorschrift

A mixture of 26 g of 3-nitro-4-chloro-benzophenone, 20 ml. of ethanol and 35 ml. of diisobutylamine is heated to 80° to 85° C. under stirring, and the reaction mixture is kept at this temperature for 6 hours. When the reaction is over, the ethanol is distilled off under reduced pressure, and 260 ml. of petroleum ether (b.p.: 40° to 100° C.) are added to the solid residue. The separated diisobutylamine hydrochloride is removed by filtration, the filtrate is evaporated, and the residue is recrystallized from ethanol. 32.7 g of 3-nitro-4-(N,N-diisobutylamino)-benzophenone are obtained, m.p. 80°-81° C. (compound B9 supra)

Aufarbeitung

  1. distillationis distilled off under reduced pressure, and 260 ml
  2. additionof petroleum ether (b.p.: 40° to 100° C.) are added to the solid residue
  3. customThe separated diisobutylamine hydrochloride is removed by filtration
  4. customthe filtrate is evaporated
  5. customthe residue is recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-2c320891cf2c46518b7194928dd404d2
Quelldatensatz
uspto-grants-1980_09
Patentnummer
US04221739

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