Hydrochloric Acid → 1-(2-Bromoethoxy)-2-(2,2,2-trifluoroethoxy)benzene

Temperatur

120 °C

To an aqueous solution (15 ml) of sodium hydroxide (0.63 g) were added 2-(2,2,2-trifluoroethoxy)phenol (2.85 g) and 1,2-dibromoethane (1.68 ml), and the mixture was reacted with stirring at 120° C. for 8 hours. To the reaction mixture was added concentrated hydrochloric acid (1.3 ml), and the mixture was extracted with diethyl ether. The extract was washed with water, dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by medium pressure liquid column chromatography on silica gel using a mixture of hexane and diethyl ether (5/1) as eluent to give 1.78 g of 1-(2-bromoethoxy)-2-(2,2,2-trifluoroethoxy)benzene as an oil

1. customthe mixture was reacted
2. extractionthe mixture was extracted with diethyl ether
3. washThe extract was washed with water
4. dry with materialdried over anhydrous magnesium sulfate
5. customThe solvent was evaporated under reduced pressure
6. customthe residue was purified by medium pressure liquid column chromatography on silica gel using
7. additiona mixture of hexane and diethyl ether (5/1) as eluent

ORD-Eintrag

ord-8817aab7fb0d4d6991795a0999b606a8

Quelldatensatz

uspto-grants-1995_02

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05387603