Ethyl bromoacetate → Ethyl 2-(2,2,2-trifluoroethoxy)phenoxyacetate

To a solution of 2-(2,2,2-trifluoroethoxy)phenol (200 mg) in dry N,N-dimethylformamide (2 ml) were added ethyl bromoacetate (138 μl) and potassium carbonate (216 mg), and the mixture was reacted with stirring at room temperature for 1 hour, and then for 1 hour at 60° C. To the reaction mixture was added ethyl acetate, and ethyl acetate solution was washed with water and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give 270 mg of ethyl 2-(2,2,2-trifluoroethoxy)phenoxyacetate as an oil.

1. customthe mixture was reacted
2. waitfor 1 hour at 60° C
3. washwas washed with water
4. dry with materialdried over anhydrous magnesium sulfate
5. customThe solvent was evaporated under reduced pressure

ORD-Eintrag

ord-8869df0e4dd243f28484cedfe31b98a8

Quelldatensatz

uspto-grants-1995_02

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05387603