Propargylamine → HCID 178457492, Verbindung

HRID 27390

Reaktionsgleichung

Reaktionsgleichung von HRID 27390
C1(S(C=C(SC)SC)(=O)=O)C=CC=CC=1.C[C:17]1[N:18]=CN[C:21]=1[CH2:22]SCCN.[C:27]1([S:33]([CH:36]=[C:37](SC)[NH:38][CH2:39][CH2:40][S:41][CH2:42][C:43]2[NH:47][CH:46]=[N:45][C:44]=2[CH3:48])(=[O:35])=[O:34])[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.C(N)C#C>>[C:27]1([S:33]([CH:36]=[C:37]([NH:18][CH2:17][C:21]#[CH:22])[NH:38][CH2:39][CH2:40][S:41][CH2:42][C:43]2[NH:47][CH:46]=[N:45][C:44]=2[CH3:48])(=[O:34])=[O:35])[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Komponenten

5

Edukt 4

HCID 239041PropargylamineHCID 12296879Benzene, [[2,2-bis(methylthio)ethenyl]sulfonyl]-HCID 178433288HCID 178433288, VerbindungHCID 178503846HCID 178503846, Verbindung

Produkt 1

HCID 178457492HCID 178457492, Verbindung

Versuchsvorschrift

Reaction of methylphenylsulfone with carbon disulphide under strongly basic conditions and treatment of the product with methyl iodide yields 1-benzenesulphonyl-2,2-bis(methylthio)ethylene. When 1-benzenesulfonyl-2,2-bis(methylthio)ethylene is reacted with 2-[(4-methyl-1H-imidazol-5-yl)-methylthio]ethylamine according to the procedure of Example 6, Step A, the product is 1-benzenesulfonyl-2-methylthio-2-{2-[(4-methyl-1H-imidazol-5-yl)methylthio]ethylamino}ethylene. Reaction of this methylthio compound with propargylamine by the procedure of Example 6, Step B, yields the title compound.

Quellen und Nachweise

ORD-Eintrag
ord-a859d5e12e754679aba9805f030eea4e
Quelldatensatz
uspto-grants-1980_09
Patentnummer
US04221737

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