1,2,3,4-Tetrahydro-6,7,8-trimethoxyisoquinoline → 2-[7-(3,4-Dimethoxyphenyl)-7-[(4-methylphenyl)thio]heptyl]-1,2,3,4-tetrahydro-6,7,8-trimethoxyisoquinoline

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	1,2,3,4-Tetrahydro-6,7,8-trimethoxyisoquinoline	HCID 192723	—
Edukt	4-[6-Bromo-1-[(4-methylphenyl)thio]heptyl]-1,2-dimethoxybenzene	HCID 19042093	—
Edukt	5,6-Dimethoxyisoindoline	HCID 20074351	—
Produkt	2-[7-(3,4-Dimethoxyphenyl)-7-[(4-methylphenyl)thio]heptyl]-1,2,3,4-tetrahydro-6,7,8-trimethoxyisoquinoline	HCID 10650882	65,7%

Reaktionsschritte

The procedure of Example 49 is repeated using 5.31 g 4-[6-bromo-1-[(4-methylphenyl)thio]heptyl]-1,2-dimethoxybenzene, 3.29 g of 5,6-dimethoxyisoindoline and 2.65 g of 6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline. This affords 4.52 g of the desired product as a yellow oil.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US05387685
Quelldatensatz	uspto-grants-1995_02
ORD ID	ord-84d33bc5cb4d4ce08f154b5169c9e3c8
Quellennotiz	uspto-grants-1995_02