Ammonia → alpha-(2-Hydroxyethyl)-2-oxo-1-pyrrolidineacetamide

HRID 27408Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 27408
[O:1]=[C:2]1[CH:6]([N:7]2[CH2:11][CH2:10][CH2:9][C:8]2=[O:12])[CH2:5][CH2:4][O:3]1.[NH3:13]>CO>[OH:3][CH2:4][CH2:5][CH:6]([N:7]1[CH2:11][CH2:10][CH2:9][C:8]1=[O:12])[C:2]([NH2:13])=[O:1]

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 23342878HCID 23342878, Verbindung

Produkt 1

HCID 23342879alpha-(2-Hydroxyethyl)-2-oxo-1-pyrrolidineacetamideAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

10.15 g (0.06 mol) of 1-(tetrahydro-2-oxo-3-furyl)-2-pyrrolidinone are dissolved in 100 ml of methanol and the solution is saturated with ammonia, the temperature rising spontaneously to 40° C. The mixture is kept at that temperature for 30 minutes, whereupon it is allowed to return to ambient temperature. The reaction mixture is then evaporated under reduced pressure and the resulting powder is recrystallized from absolute ethanol. 10 g of alpha-(2-hydroxyethyl)-2-oxo-1-pyrrolidineacetamide are obtained. M.P.: 164°-165° C.; yield: 90% of theory.

Aufarbeitung

  1. customrising spontaneously to 40° C
  2. customto return to ambient temperature
  3. customThe reaction mixture is then evaporated under reduced pressure
  4. customthe resulting powder is recrystallized from absolute ethanol

Quellen und Nachweise

ORD-Eintrag
ord-3be00ad94a5d4ee49aaca088c2be7f15
Quelldatensatz
uspto-grants-1980_09
Patentnummer
US04221789

Notizen zur Reaktion

Wird geladen…