Methanol → HCID 178484885, Verbindung

HRID 274218

Reaktionsgleichung

Reaktionsgleichung von HRID 274218
S(Cl)([Cl:3])=O.[CH3:5][NH:6][C@H:7]([C:15]([OH:17])=[O:16])[CH2:8][CH2:9][CH2:10][NH:11][C:12](=[NH:14])[NH2:13].[CH3:18]O>>[ClH:3].[ClH:3].[CH3:18][O:16][C:15](=[O:17])[C@H:7]([CH2:8][CH2:9][CH2:10][NH:11][C:12](=[NH:13])[NH2:14])[NH:6][CH3:5]

Komponenten

4

Edukt 3

HCID 887MethanolHCID 24386Thionyl Chloride2×HCID 178484884HCID 178484884, Verbindung

Produkt 1

HCID 178484885HCID 178484885, Verbindung

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

6.4 ml of thionyl chloride are added dropwise to a suspension of 15.06 g of N-methylarginine in 50 ml of absolute methanol at -10° C. The mixture is then allowed to come to room temperature, while stirring. Since starting material is still present after a reaction time of 17 hours, a further 9.6 ml of thionyl chloride are added in portions, the mixture is heated at 40° C. for 4 hours, the insoluble material is filtered off with suction and the filtrate is concentrated. The oily residue is dissolved in water, the insoluble material is filtered off and the product is freeze-dried.

Aufarbeitung

  1. customto come to room temperature
  2. customafter a reaction time of 17 hours
  3. filtrationthe insoluble material is filtered off with suction
  4. concentrationthe filtrate is concentrated
  5. dissolutionThe oily residue is dissolved in water
  6. filtrationthe insoluble material is filtered off
  7. customthe product is freeze-dried

Quellen und Nachweise

ORD-Eintrag
ord-b37a7ab4c7a04dd1a6fb0a747db9b236
Quelldatensatz
uspto-grants-1995_02
Patentnummer
US05389614

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