2H-Azepine, 3,4,5,6-tetrahydro-7-methoxy- → 2-(alpha-Cyano-4-chlorobenzylidene)perhydroazepine

Beteiligte Stoffe

Reaktionsschritte

Agitate a mixture of 5.0 g of 4-chlorobenzyl cyanide, 5.5 g of caprolactim methyl ether and 0.5 g of diazabicyclo [5.4.0]undec-5-ene under nitrogen for 18 hours at 125°. Cool the thus-obtained reaction mixture to ambient temperature and then rub down the crystallizing residue with 20 ml of methyl alcohol before filtering to obtain 5.5 g of the title compound. Recrystallize this compound from methyl alcohol to obtain a product with a MP of 114° to 117°.

Herkunft & Nachweise