Diethylformamide → 2-Amino-6-chloropurine

HRID 274317

Reaktionsgleichung

Reaktionsgleichung von HRID 274317
C(N(CC)C=O)C.C(N1CCCCC1)=O.C(N(C=[N:22][C:23]1[N:31]=[C:30]2[C:26]([NH:27][CH:28]=[N:29]2)=[C:25]([Cl:32])[N:24]=1)CC)C.N1(C=NC2N=C3C(NC=N3)=C(Cl)N=2)CCCCC1>>[NH2:22][C:23]1[N:31]=[C:30]2[C:26]([NH:27][CH:28]=[N:29]2)=[C:25]([Cl:32])[N:24]=1

Komponenten

5

Edukt 4

HCID 12051DiethylformamideHCID 174291-PiperidinecarboxaldehydeHCID 538601682-Diethylaminomethyleneamino-6-chloropurineHCID 539799982-Piperidinomethyleneamino-6-chloropurine

Produkt 1

HCID 53603492-Amino-6-chloropurine

Versuchsvorschrift

The reaction is carried out in the same manner as in Example 2 except that N,N-diethylformamide or N-formylpiperidine is used in the place of N,N-dimethylformamide to yield, respectively, a crystal of 2-diethylaminomethyleneamino-6-chloropurine or 2-piperidinomethyleneamino-6-chloropurine as an intermediate for further synthesis. A further treatment is carried out in the same manner as in Example 2 on these crystals to yield a white crystal of 2-amino-6-chloropurine.

Aufarbeitung

  1. customto yield

Quellen und Nachweise

ORD-Eintrag
ord-98a2bfc10ace44b1b5056c5010171480
Quelldatensatz
uspto-grants-1995_02
Patentnummer
US05389637

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