Triethylene Glycol → 2-(4-Chlorobenzyl)-1-[4-(4-fluorophenyl)butyl]perhydroazepine

Beteiligte Stoffe

Reaktionsschritte

Heat 0.5 g of the title compound of Example 39 with 1 ml of hydrazine hydrate, 0.5 g of potassium hydroxide and 5 ml of triglycol for 2 hours at 165°. Cool the resulting reaction mixture to ambient temperature. Mix the cooled reaction mixture with water and diethyl ether. Dry the ether phase over sodium sulfate and then concentrate it to obtain 0.3 g of the title compound as a viscous oil.

Herkunft & Nachweise