Glycolic Acid → 2-(Hydroxymethyl)-Alpha,Alpha-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol

HRID 274394Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 274394
[NH2:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([C:11]=1[NH:12][CH2:13][C:14]([OH:17])([CH3:16])[CH3:15])=[CH:9][CH:8]=[CH:7][CH:6]=2.[C:18](O)(=O)[CH2:19][OH:20]>>[CH3:16][C:14]([CH3:15])([OH:17])[CH2:13][N:12]1[C:11]2[C:10]3[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=3[N:4]=[CH:3][C:2]=2[N:1]=[C:18]1[CH2:19][OH:20]

Komponenten

3

Edukt 2

HCID 757Glycolic AcidHCID 149869411-((3-Aminoquinolin-4-yl)amino)-2-methylpropan-2-ol

Produkt 1

HCID 226726582-(Hydroxymethyl)-Alpha,Alpha-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol

Versuchsvorschrift

Using the general method of Example 24, 3-amino-4-(2-hydroxy-2-methylpropylamino)quinoline (45 g, 0.19 mol) was reacted with glycolic acid to provide 35.7 g of the desired product as a tan solid. The structure was confirmed by nuclear magnetic resonance spectroscopy.

Quellen und Nachweise

ORD-Eintrag
ord-b6cc2915c15e462fbaf9323fdd6900a0
Quelldatensatz
uspto-grants-1995_02
Patentnummer
US05389640

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