Phosphorus oxychloride → 9-Chloro-7-dodecyl-1,2,3,4-tetrahydroacridine

HRID 274868

Reaktionsgleichung

Reaktionsgleichung von HRID 274868
[CH2:1]([C:13]1[CH:26]=[C:25]2[C:16]([N:17]=[C:18]3[C:23](=[C:24]2O)[CH2:22][CH2:21][CH2:20][CH2:19]3)=[CH:15][CH:14]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].O=P(Cl)(Cl)[Cl:30]>>[Cl:30][C:24]1[C:25]2[C:16]([N:17]=[C:18]3[C:23]=1[CH2:22][CH2:21][CH2:20][CH2:19]3)=[CH:15][CH:14]=[C:13]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])[CH:26]=2

Komponenten

3

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 178442815HCID 178442815, Verbindung

Produkt 1

HCID 200889899-Chloro-7-dodecyl-1,2,3,4-tetrahydroacridine

Versuchsvorschrift

Three grams of 7-dodecyl-9-hydroxy-1,2,3,4-tetrahydroacridine was refluxed for 30 minutes in 30 mL of POCl3. At the end of this time the POCl3 was evaporated and the residue distributed between aqueous NH3 and ethyl ether. The organic phase was dried and evaporated to give 9-chloro-7-dodecyl-1,2,3,4-tetrahydroacridine (3.0 g) as a solid. A small sample was recrystallized from methanol to give fine needles, mp 36°-38°.

Aufarbeitung

  1. customAt the end of this time the POCl3 was evaporated
  2. customThe organic phase was dried
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-98a53e2b3cc04ca08e646f733569aa39
Quelldatensatz
uspto-grants-1995_02
Patentnummer
US05391553

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