Pyridine → HCID 20077588, Verbindung

HRID 275040

Reaktionsgleichung

Reaktionsgleichung von HRID 275040
[Cl:1][C:2]1[C:8]([CH3:9])=[CH:7][CH:6]=[C:5]([Cl:10])[C:3]=1[NH2:4].C(N[C:14]1[NH:18][N:17]=[C:16]([S:19](Cl)(=[O:21])=[O:20])[N:15]=1)=O.[OH-:23].[Na+].C(Cl)(Cl)Cl.[N:29]1[CH:34]=CC=CC=1>>[Cl:1][C:2]1[C:8]([CH3:9])=[CH:7][CH:6]=[C:5]([Cl:10])[C:3]=1[NH:4][S:19]([C:16]1([NH:29][CH:34]=[O:23])[N:17]=[N:18][CH:14]=[N:15]1)(=[O:20])=[O:21]

Komponenten

6

Edukt 5

HCID 1049PyridineHCID 6212ChloroformHCID 14798Sodium HydroxideHCID 1165292,6-Dichloro-3-methylanilineHCID 178522608HCID 178522608, Verbindung

Produkt 1

HCID 20077588HCID 20077588, Verbindung

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

To a mixture of 1 g (5.2 mmol) of 2,6-dichloro-3-methylaniline in 2 ml pyridine was added 1 g (4.7 mmol) of 5-formylamino-3-chlorosulfonyl-1,2,4-triazole over a period of 5 minutes. The mixture was heated with stirring to 70° C. for 4 hours. It was then cooled and dispersed between 25 ml of 1N aqueous sodium hydroxide and 50 ml of chloroform. The aqueous layer was recovered, extracted with more chloroform, and acidified with aqueous hydrochloric acid. The solids that formed were collected by filtration and dried to obtain 1.0 g (59 percent of theory) of the title compound, m.p. 275°-279° C. The infrared and carbon nmr spectra were consistent with the assigned structure.

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureIt was then cooled
  3. customThe aqueous layer was recovered
  4. extractionextracted with more chloroform
  5. customThe solids that formed
  6. filtrationwere collected by filtration
  7. customdried

Quellen und Nachweise

ORD-Eintrag
ord-a0fb4fe0214d4f7e9cc372b0d6acbc71
Quelldatensatz
uspto-grants-1995_02
Patentnummer
US05391759

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