Ethylene Glycol → 2-(2-Hydroxyethoxymethyl)pyrazine

HRID 27514

Reaktionsgleichung

Cl[CH2:2][C:3]1[CH:8]=[N:7][CH:6]=[CH:5][N:4]=1.[Na].[CH2:10]([OH:13])[CH2:11][OH:12]>>[OH:12][CH2:11][CH2:10][O:13][CH2:2][C:3]1[CH:8]=[N:7][CH:6]=[CH:5][N:4]=1

Komponenten

Edukt 3

HCID 174Ethylene Glycol

HCID 170169Pyrazine, 2-(chloromethyl)-

HCID 5360545Sodium

Produkt 1

HCID 205675442-(2-Hydroxyethoxymethyl)pyrazine

Versuchsvorschrift

2-Chloromethylpyrazine is reacted with the sodium salt of ethylene glycol to give 2-(2-hydroxyethoxymethyl)pyrazine which is treated with thionyl chloride to give 2-(2-chloroethoxymethyl)pyrazine. Using this intermediate in place of 4-(3-chloropropoxy(methylimidazole in the procedure of Example 22 gives the title compound.

Quellen und Nachweise

ORD-Eintrag: ord-738a1d3057c54f41b9c4d43bb5ae35b6
Quelldatensatz: uspto-grants-1980_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04221802

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