Ethylenediamine → N-(pyrazinylmethyl)ethylenediamine

Reaktionsgleichung

[CH2:1]([NH2:4])[CH2:2][NH2:3].Cl[CH2:6][C:7]1[CH:12]=[N:11][CH:10]=[CH:9][N:8]=1>>[N:8]1[CH:9]=[CH:10][N:11]=[CH:12][C:7]=1[CH2:6][NH:3][CH2:2][CH2:1][NH2:4]

Komponenten

Edukt 2

HCID 3301Ethylenediamine

HCID 170169Pyrazine, 2-(chloromethyl)-

Produkt 1

HCID 13910894N-(pyrazinylmethyl)ethylenediamine

Versuchsvorschrift

Ethylenediamine is reacted with 2-chloromethylpyrazine by the procedure of Example 34 to give N-(2-pyrazinylmethyl)ethylenediamine. Heating the compound with S-methylisothiourea in water under reflux for 3 hours by the procedure of Example 1 gives 2-(2-pyrazinylmethylamino)ethylguanidine.

Quellen und Nachweise

ORD-Eintrag: ord-822543f8f7d94c328338ce0555060a74
Quelldatensatz: uspto-grants-1980_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04221802

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