HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-(Trifluoromethyl)phenylhydrazine → 2-(3-Trifluoromethylbenzoyl)nicotinic acid (4-trifluoromethylphenyl)hydrazone
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-(Trifluoromethyl)phenylhydrazine | HCID 136200 | — |
| Edukt | 2-(3-Trifluoromethylbenzoyl)nicotinic acid | HCID 20078895 | — |
| Katalysator | p-Toluenesulfonic acid | HCID 6101 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | 2-(3-Trifluoromethylbenzoyl)nicotinic acid (4-trifluoromethylphenyl)hydrazone | HCID 178519560 | 80,7% |
Reaktionsschritte
2-(3-Trifluoromethylbenzoyl)nicotinic acid (0.5 g), 4-trifluoromethylphenylhydrazine (0.3 g) and para-toluene sulphonic acid (0.001 g) were stirred in methanol at room temperature for 22 hours. Solvent was evaporated. The residue was triturated in cold toluene then dried to yield the title compound as a beige solid (0.62 g), m.p. 127°-129° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05393730 |
| Quelldatensatz | uspto-grants-1995_02 |
| ORD ID | ord-0f21748979904a6cb9e4027cefd1fe85 |
| Quellennotiz | uspto-grants-1995_02 |