Thionyl Chloride → 2-(3-Trifluoromethylbenzoyl)nicotinoyl chloride

HRID 275260

Reaktionsgleichung

Reaktionsgleichung von HRID 275260
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([CH:17]=[CH:18][CH:19]=1)[C:6]([C:8]1[N:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10](O)=[O:11])=[O:7].S(Cl)([Cl:24])=O>>[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[C:5]([CH:17]=[CH:18][CH:19]=1)[C:6]([C:8]1[N:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10]([Cl:24])=[O:11])=[O:7]

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 200788952-(3-Trifluoromethylbenzoyl)nicotinic acid

Produkt 1

HCID 200876762-(3-Trifluoromethylbenzoyl)nicotinoyl chloride

Versuchsvorschrift

A mixture of 2-(3-trifluoromethylbenzoyl)nicotinic acid (1.8 g) and thionyl chloride (10 ml) was heated at reflux for 3.5 hours. Excess reagent was removed by evaporation to yield 2-(3-trifluoromethylbenzoyl)nicotinoyl chloride as a red-brown gum (2 g) which was used in the next step without further purification.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 3.5 hours
  3. customExcess reagent was removed by evaporation

Quellen und Nachweise

ORD-Eintrag
ord-3881d5926da84b78b87d9ae74e1a462f
Quelldatensatz
uspto-grants-1995_02
Patentnummer
US05393730

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