Potassium Carbonate → 5,6a(R),7,8,9,9a(S)-Hexahydro-2,5-dimethyl-3-[(trimethylacetoxy)methyl]-cyclopent[4,5]imidazo[2,1-b]purin-4(3H)-one

Beteiligte Stoffe

Reaktionsschritte

Treat 5,6a(R),7,8,9,9a(S)-hexahydro-2,5-dimethylcyclopent[4,5]imidazo[2,1-b]purin-4(3H)-one from Example 19a (0.28 g, 1.1 mmol) in DMF with (4 ml) with potassium carbonate (0.24 g) and chloromethylpivalate (0.2 ml, 1.4 mmol) at 35° C. for 6 hr. Cool and filter the reaction mixture. Partition the filtrate with brine and ethyl acetate: THF 1:1. Dry and concentrate the organic layer to give the title compound as a powder.

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