(2S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)hexanoic acid → 9H-fluoren-9-ylmethyl [(S)-1-[[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]carbamoyl]pentyl]carbamate

Beteiligte Stoffe

Reaktionsschritte

Analogously to the procedure described in Example 1, paragraph (c), by condensing (1S,2R,3S)-3-amino-4-cyclohexyl-1-cyclopropyl-1,2-butanediol and Fmoc-norleucine there was obtained 9H-fluoren-9-ylmethyl [(S)-1-[[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]carbamoyl]pentyl]carbamate which, after reaction with piperidine in methylene chloride, yielded (S)-2-amino-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]hexanamide as a colourless foam, MS: 322 (M-H2)+.

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