(1S,2R,3S)-3-amino-4-cyclohexyl-1-cyclopropyl-1,2-butanediol → rac-alpha-amino-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]-3-(furan-2-yl)propionamide

Beteiligte Stoffe

Reaktionsschritte

In an analogous manner to that described above, by the condensation of (RS)-α-(1-benzyloxyformamido)-3-(furan-2-yl)propionic acid [J. Biol. Chem. 171, 383 (1947)]and (1S,2R,3S)-3-amino-4-cyclohexyl-1-cyclopropyl-1,2-butanediol followed by catalytic hydrogenation there was obtained rac-α-amino-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]-3-(furan-2-yl)propionamide, MS: 365 (M+H)+, as a colourless foam.

Herkunft & Nachweise