Methyl Lactate → Behenyl Lactate

HRID 275640Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 275640
[C:1]([O:6][CH3:7])(=[O:5])[CH:2]([CH3:4])[OH:3].[CH2:8](O)[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]C.[H-].[Na+]>>[C:1]([O:6][CH2:7][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH3:8])(=[O:5])[CH:2]([CH3:4])[OH:3]

Komponenten

4

Edukt 3

HCID 11040Methyl LactateHCID 12620Behenyl AlcoholHCID 24758Sodium hydride

Produkt 1

HCID 54124846Behenyl Lactate

Reaktionsbedingungen

Temperatur
160 °C

Versuchsvorschrift

Behenyl Lactate was prepared by reacting methyl lactate (Aldrich Chemical Company, Inc. of Milwaukee, Wis.) with Lanette 22 (behenyl alcohol, 90%, Henkel Corp. of Ambler, Pa.) in a transesterification reaction according to the following method: 0.2 g sodium hydride (60% in mineral oil) was added to 32.6 grams Lanette 22 at 70° C. in a 3-neck 250ml glass flask purged with nitrogen and inserted with overhead stirrer, Dean Stark trap, thermometer, and condenser. To this was slowly added 9.4 g of methyl lactate and the contents were slowly heated to 160° C. and held at that temperature for one hour. At this temperature over 2 ml of methanol was collected. The contents were heated to 200° C. with a nitrogen sweep to remove any volatile components. After approximately 15 minutes at 200° C. the contents were cooled. Upon cooling the product crystallized and had a melting point of approximately 57° C.

Aufarbeitung

  1. customin a transesterification reaction
  2. custompurged with nitrogen
  3. custominserted with overhead stirrer
  4. customAt this temperature over 2 ml of methanol was collected
  5. temperatureThe contents were heated to 200° C. with a nitrogen sweep
  6. customto remove any volatile components
  7. temperatureAfter approximately 15 minutes at 200° C. the contents were cooled
  8. temperatureUpon cooling the product
  9. customcrystallized

Quellen und Nachweise

ORD-Eintrag
ord-f976a1c80cee43148409f29d61662ecf
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06352701B1

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