N-methyl-N-methyloxy-2-benzyloxycarbonylamino-5-methyloxy-benzamide → Benzamide, 2-amino-N,5-dimethoxy-N-methyl-

HRID 275859Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 275859
[CH3:1][N:2]([O:24][CH3:25])[C:3](=[O:23])[C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[NH:12]C(OCC1C=CC=CC=1)=O>C(OCC)(=O)C.CO.[H][H].[C].[Pd]>[CH3:1][N:2]([O:24][CH3:25])[C:3](=[O:23])[C:4]1[CH:9]=[C:8]([O:10][CH3:11])[CH:7]=[CH:6][C:5]=1[NH2:12]

Komponenten

6

Edukt 1

HCID 18315335N-methyl-N-methyloxy-2-benzyloxycarbonylamino-5-methyloxy-benzamide

Produkt 1

HCID 11514001Benzamide, 2-amino-N,5-dimethoxy-N-methyl-Ausbeute 104,2 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittelHCID 178418361HCID 178418361, VerbindungLösungsmittel

Versuchsvorschrift

In a mixture of ethyl acetate (8 ml) and methanol (10 ml) was dissolved N-methyl-N-methyloxy-2-benzyloxycarbonylamino-5-methyloxy-benzamide (0.55 g). To the solution was added 10% palladium-carbon (0.1 g). The mixture was stirred for 40 minutes at ordinary temperature under atmospheric pressure in hydrogen streams. The reaction mixture was subjected to filtration, and the filtrate was concentrated under reduced pressure. From the concentrate, N-methyl-N-methyloxy 2-amino-5-methyloxy-benzamide (0.35 g) was obtained.

Aufarbeitung

  1. filtrationThe reaction mixture was subjected to filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-3151efb2da3b49d0be0a0571a2d3f433
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06352982B1

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