Chloral → alpha-Trichloromethyl-2-thiophenemethanol

HRID 27591

Reaktionsgleichung

Reaktionsgleichung von HRID 27591
[S:1]1[CH:5]=[CH:4][CH:3]=[CH:2]1.[Cl:6][C:7]([Cl:11])([Cl:10])[CH:8]=[O:9]>CCCCCCC>[Cl:6][C:7]([Cl:11])([Cl:10])[CH:8]([C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[OH:9]

Komponenten

4

Edukt 2

HCID 6407ChloralHCID 8030Thiophene

Produkt 1

HCID 12566320alpha-Trichloromethyl-2-thiophenemethanolAusbeute 20 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8900HeptaneLösungsmittel

Versuchsvorschrift

Thiophene (4.2 g, 50 mmol) and trichloroacetaldehyde (7.35 g, 50 mmol) were dissolved in n-heptane (25 ml). The solution was heated under reflux for 3.5 hr. under a Soxleht apparatus in which Amberlyst 15 (4.2 g) had been placed. After cooling, the n-heptane solution was concentrated, and the residue was purified by distillation to give 2.32 g of α-trichloromethyl-2-thiophenemethanol boiling at 98°-100° C./1.0 mmHg.

Aufarbeitung

  1. temperatureThe solution was heated
  2. temperatureunder reflux for 3.5 hr
  3. temperatureAfter cooling
  4. concentrationthe n-heptane solution was concentrated
  5. distillationthe residue was purified by distillation

Quellen und Nachweise

ORD-Eintrag
ord-28b3a49b4b8d4b40a1cbd8ddf9546e9f
Quelldatensatz
uspto-grants-1980_09
Patentnummer
US04221915

Verknüpfte Notizen

Wird geladen…