Triethylamine → 5,6-Dimethyl-2-chloro-4-(5-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine

HRID 275944

Reaktionsgleichung

Reaktionsgleichung von HRID 275944
[CH3:1][CH:2]1[C:11]2[C:6](=[C:7]([O:12][CH3:13])[CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][NH:3]1.C(N(CC)CC)C.[CH3:21][C:22]1[C:23](Cl)=[N:24][C:25]([Cl:29])=[N:26][C:27]=1[CH3:28]>CN(C)C=O>[CH3:21][C:22]1[C:23]([N:3]2[CH2:4][CH2:5][C:6]3[C:11](=[CH:10][CH:9]=[CH:8][C:7]=3[O:12][CH3:13])[CH:2]2[CH3:1])=[N:24][C:25]([Cl:29])=[N:26][C:27]=1[CH3:28]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 2415532,4-Dichloro-5,6-dimethylpyrimidineHCID 183156461-Methyl-5-methoxy-1,2,3,4-tetrahydro-isoquinoline

Produkt 1

HCID 183158305,6-Dimethyl-2-chloro-4-(5-methoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidineAusbeute 70,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

After 1-methyl-5-methoxy-1,2,3,4-tetrahydroisoquinoline(0.9 g, 5.1 mmol) and triethylamine(0.7 ml, 5.1 mmol) were added to a suspension of 5,6-dimethyl-2,4-dichloropyrimidine(0.8 g, 4.64 mmol) in dimethylformamide, 1.0 g of the titled compound was obtained in accordance with the same procedure as in Step 1 of Example 35. (Yield: 70.3%)

Quellen und Nachweise

ORD-Eintrag
ord-0543e04e7ee04fb8af785085f92c62f4
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06352993B1

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