Thionyl Chloride → 1-(Chloromethyl)-4-phenoxybenzene

Reaktionsgleichung

S(Cl)([Cl:3])=O.[O:5]([C:12]1[CH:19]=[CH:18][C:15]([CH2:16]O)=[CH:14][CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>>[O:5]([C:12]1[CH:19]=[CH:18][C:15]([CH2:16][Cl:3])=[CH:14][CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Komponenten

Edukt 2

HCID 24386Thionyl Chloride

HCID 826195(4-Phenoxyphenyl)methanol

Produkt 1

HCID 5209941-(Chloromethyl)-4-phenoxybenzeneAusbeute 97,2 %

Reaktionsbedingungen

Temperatur: 80 °C

Versuchsvorschrift

Thionyl chloride (13.34 g) was added to 4.06 g of 4-phenoxybenzyl alcohol, and the mixture was stirred at 80° C. for 3.5 hours. After the completion of the concentration, the reaction mixture was extracted with ethyl acetate and with water. The organic layer was concentrated to give 4.31 g of 4-phenoxybenzyl chloride.

Aufarbeitung

concentrationAfter the completion of the concentration
extractionthe reaction mixture was extracted with ethyl acetate and with water
concentrationThe organic layer was concentrated

Quellen und Nachweise

ORD-Eintrag: ord-e48630886bf3471b8d19ba088efbd56b
Quelldatensatz: uspto-grants-2002_03
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06352985B1

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