Thionyl Chloride → 1-(Chloromethyl)-4-phenoxybenzene

HRID 276076

Reaktionsgleichung

Reaktionsgleichung von HRID 276076
S(Cl)([Cl:3])=O.[O:5]([C:12]1[CH:19]=[CH:18][C:15]([CH2:16]O)=[CH:14][CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>>[O:5]([C:12]1[CH:19]=[CH:18][C:15]([CH2:16][Cl:3])=[CH:14][CH:13]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 826195(4-Phenoxyphenyl)methanol

Produkt 1

HCID 5209941-(Chloromethyl)-4-phenoxybenzeneAusbeute 97,2 %

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

Thionyl chloride (13.34 g) was added to 4.06 g of 4-phenoxybenzyl alcohol, and the mixture was stirred at 80° C. for 3.5 hours. After the completion of the concentration, the reaction mixture was extracted with ethyl acetate and with water. The organic layer was concentrated to give 4.31 g of 4-phenoxybenzyl chloride.

Aufarbeitung

  1. concentrationAfter the completion of the concentration
  2. extractionthe reaction mixture was extracted with ethyl acetate and with water
  3. concentrationThe organic layer was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-e48630886bf3471b8d19ba088efbd56b
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06352985B1

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