Thionyl Chloride → N-cyclooctyl-N-(2-chloroethyl)ammonium chloride

HRID 276336

Reaktionsgleichung

Reaktionsgleichung von HRID 276336
[CH:1]1([NH:9][CH2:10][CH2:11]O)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.O=S(Cl)[Cl:15]>>[Cl-:15].[CH:1]1([NH2+:9][CH2:10][CH2:11][Cl:15])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 132882152-(Cyclooctylamino)ethan-1-ol

Produkt 1

HCID 18316362N-cyclooctyl-N-(2-chloroethyl)ammonium chloride

Versuchsvorschrift

2-Hydroxyethylamine was reacted with cyclooctyl bromide according to Method B2a to give N-cyclooctyl-N-(2-hydroxyethyl)amine. The alcohol was reacted with SOCl2 according to Method B7c to give N-cyclooctyl-N-(2-chloroethyl)ammonium chloride. The chloroethylamine was reacted with 2-methyl-4-nitrophenyl isothiocyanate to give 2-(2-methyl-4-nitrophenylimino)-3-cyclooctyl-1,3-thiazolidine.

Quellen und Nachweise

ORD-Eintrag
ord-c86a622b794946bf90715c21d4a73ad0
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06353006B1

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