Thionyl Chloride → N-cyclobutylmethyl-N-(2-chloroethyl)ammonium chloride

HRID 276362Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 276362
[CH:1]1([CH2:5][NH:6][CH2:7][CH2:8]O)[CH2:4][CH2:3][CH2:2]1.O=S(Cl)[Cl:12]>>[Cl-:12].[CH:1]1([CH2:5][NH2+:6][CH2:7][CH2:8][Cl:12])[CH2:4][CH2:3][CH2:2]1

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 183163062-((Cyclobutylmethyl)amino)ethanol

Produkt 1

HCID 18316353N-cyclobutylmethyl-N-(2-chloroethyl)ammonium chloride

Versuchsvorschrift

2-Hydroxyethylamine was reacted with cyclobutylmethyl bromide according to Method B2a to give N-cyclobutylmethyl-N-(2-hydroxyethyl)amine. The alcohol was reacted with SOCl2 according to Method B7c to give N-cyclobutylmethyl-N-(2-chloroethyl)ammonium chloride. The chloroethylamine was reacted with 2,3-dimethylphenyl isothiocyanate to give 2-(2,3-dimethylphenylimino)-3-(cyclobutylmethyl)-1,3-thiazolidine.

Quellen und Nachweise

ORD-Eintrag
ord-f9a9d260afb14b12ac90bccea1686a74
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06353006B1

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