2-Ethyl-4-cyanophenyl isothiocyanate → 2-(4-Cyano-2-ethylphenylimino)-3-(4-chlorobenzyl)-1,3-thiazolidine

HRID 276413

Reaktionsgleichung

Reaktionsgleichung von HRID 276413
[Cl-].[Cl:2][C:3]1[CH:13]=[CH:12][C:6]([CH2:7][NH2+:8][CH2:9][CH2:10]Cl)=[CH:5][CH:4]=1.[C:14]([C:16]1[CH:21]=[CH:20][C:19]([N:22]=[C:23]=[S:24])=[C:18]([CH2:25][CH3:26])[CH:17]=1)#[N:15]>>[C:14]([C:16]1[CH:21]=[CH:20][C:19]([N:22]=[C:23]2[N:8]([CH2:7][C:6]3[CH:12]=[CH:13][C:3]([Cl:2])=[CH:4][CH:5]=3)[CH2:9][CH2:10][S:24]2)=[C:18]([CH2:25][CH3:26])[CH:17]=1)#[N:15]

Komponenten

3

Edukt 2

HCID 183161022-Ethyl-4-cyanophenyl isothiocyanateHCID 18316438N-(4-chlorobenzyl)-N-(2-chloroethyl)ammonium chloride

Produkt 1

HCID 183160942-(4-Cyano-2-ethylphenylimino)-3-(4-chlorobenzyl)-1,3-thiazolidine

Versuchsvorschrift

2-Hydroxyethylamine was reacted with 4-chlorobenzyl bromide according to Method B2a to give N-(4-chlorobenzyl)-N-(2-hydroxyethyl)amine. The alcohol was reacted with SOCl2 according to Method B7c to give N-(4-chlorobenzyl)-N-(2-chloroethyl)ammonium chloride. The chloroethylamine was reacted with 4-cyano-2-ethylphenyl isothiocyanate to give 2-(4-cyano-2-ethylphenylimino)-3-(4-chlorobenzyl)-1,3-thiazolidine.

Quellen und Nachweise

ORD-Eintrag
ord-3458ebfbe13b4a778daf071b0cae48e9
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06353006B1

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