Ethanolamine → HCID 178426109, Verbindung

HRID 276463

Reaktionsgleichung

Reaktionsgleichung von HRID 276463
O[CH2:2][C@@H:3]([NH2:8])[CH2:4][CH:5]([CH3:7])[CH3:6].COC(=O)[C@H](CC(C)C)N.OCCN.[Cl:23][C:24]1[CH:29]=[CH:28][C:27]([N:30]=[C:31]=[S:32])=[C:26]([CH3:33])[CH:25]=1>>[Cl:23][C:24]1[CH:29]=[CH:28][C:27]([N:30]=[C:31]2[NH:8][C@@H:3]([CH2:4][CH:5]([CH3:7])[CH3:6])[CH2:2][S:32]2)=[C:26]([CH3:33])[CH:25]=1

Komponenten

5

Edukt 4

HCID 700EthanolamineHCID 65105(+)-L-Leucine methyl esterHCID 900213-Chloro-6-isothiocyanatotolueneHCID 111307L-Leucinol

Produkt 1

HCID 178426109HCID 178426109, Verbindung

Versuchsvorschrift

(1S)-1-(Hydroxymethyl)-3-methylbutylamine was made from (L)-leucine methyl ester as described in Method B1b. The 2-hydroxyethylamine was converted to (1S)-1-(chloromethyl)-3-methylbutanammonium chloride as described in Method B7a. 4-Chloro-2-methylphenyl isothiocyanate was reacted with (1S)-1-(chloromethyl)-3-methylbutanammonium chloride according to Method C1a to give (4S)-2-(4-Chloro-2-methylphenylimino)-4-isobutyl-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to give (4S)-2-(4-chloro-2-methylphenylimino)-3,4-diisobutyl-1,3-thiazolidine.

Quellen und Nachweise

ORD-Eintrag
ord-c4da1592dd674767a820aab616edfc66
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06353006B1

Verknüpfte Notizen

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