Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Ethanolamine | HCID 700 | — |
| Edukt | 4-Chloro-3-(trifluoromethyl)aniline | HCID 67574 | — |
| Edukt | L-Isoleucine, methyl ester | HCID 75735 | — |
| Edukt | 1-Chloro-4-isothiocyanato-2-(trifluoromethyl)benzene | HCID 520026 | — |
| Edukt | (2S)-2-amino-3-methylpentan-1-ol | HCID 11789185 | — |
| Produkt | HCID 178445841 | HCID 178445841 | — |
Reaktionsschritte
(1S)-1-(Hydroxymethyl)-2-methylbutylamine was made from (L)-isoleucine methyl ester as described in Method B1b. The 2-hydroxyethylamine was converted to (1S)-1-(chloromethyl)-2-methylbutanammonium chloride as described in Method B7a. 4-Chloro-3-(trifluoromethyl)aniline was converted to 4-chloro-3-(trifluoromethyl)phenyl isothiocyanate according to Method A2a, Step 3 4-Chloro-3-(trifluoromethyl)phenyl isothiocyanate was reacted with (1S)-1-(chloromethyl)-2-methylbutanammonium chloride according to Method C1a to give (4S)-2-(4-chloro-3-(trifluoromethyl)phenylimino)-4-(2-butyl)-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to afford (4S)-2-(4-chloro-3-(trifluoromethyl)phenylimino)-4-(2-butyl)-3-isobutyl-1,3-thiazolidine.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US06353006B1 |
|---|
| Quelldatensatz | uspto-grants-2002_03 |
|---|
| ORD ID | ord-5fa6ed4278f44503a2578b2b396b72e8 |
|---|
| Quellennotiz | uspto-grants-2002_03 |
|---|
