Reaktionsgleichung
O[CH2:2][C@@H:3]([NH2:8])[CH:4]([CH3:7])[CH2:5][CH3:6].COC(=O)[C@H]([C@H](CC)C)N.OCCN.[C:23]([C:25]1[CH:30]=[CH:29][C:28]([N:31]=[C:32]=[S:33])=[C:27]([CH2:34][CH3:35])[CH:26]=1)#[N:24]>>[C:23]([C:25]1[CH:30]=[CH:29][C:28]([N:31]=[C:32]2[NH:8][C@@H:3]([CH:4]([CH2:5][CH3:6])[CH3:7])[CH2:2][S:33]2)=[C:27]([CH2:34][CH3:35])[CH:26]=1)#[N:24]Komponenten
5
Versuchsvorschrift
(1S)-1-(Hydroxymethyl)-2-methylbutylamine was made from (L)-isoleucine methyl ester as described in Method B1b. The 2-hydroxyethylamine was converted to (1S)-1-(chloromethyl)-2-methylbutanammonium chloride as described in Method B7a. 4-Cyano-2-ethylphenyl isothiocyanate was reacted with (1S)-1-(chloromethyl)-2-methylbutanammonium chloride to Method C1a to give (4S)-2-(4-cyano-2-ethylphenylimino)-4-(2-butyl)-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to give (4S)-2-(4-cyano-2-ethylphenylimino)-4-butyl-3-isobutyl-1,3-thiazolidine.
Quellen und Nachweise
- ORD-Eintrag
- ord-8064e901706d4b8e8961a5ab29f5ec7f
- Quelldatensatz
- uspto-grants-2002_03
- Patentnummer
- US06353006B1
Verknüpfte Notizen
Wird geladen…