5-Chlorothieno[3,2-b]pyridine-2-sulfonyl chloride → 5-Chlorothieno[3,2-b]pyridine-2-sulfonic acid [1-(5-cyano-2-hydroxybenzyl)-2-oxo-pyrrolidin-3-(S)-yl]-amide

HRID 2765

Reaktionsgleichung

Reaktionsgleichung von HRID 2765
Cl.[OH:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][C:4]=1[CH2:11][N:12]1[CH2:16][CH2:15][C@H:14]([NH2:17])[C:13]1=[O:18].[Cl:19][C:20]1[N:25]=[C:24]2[CH:26]=[C:27]([S:29](Cl)(=[O:31])=[O:30])[S:28][C:23]2=[CH:22][CH:21]=1>>[C:7]([C:6]1[CH:9]=[CH:10][C:3]([OH:2])=[C:4]([CH:5]=1)[CH2:11][N:12]1[CH2:16][CH2:15][C@H:14]([NH:17][S:29]([C:27]2[S:28][C:23]3[C:24](=[N:25][C:20]([Cl:19])=[CH:21][CH:22]=3)[CH:26]=2)(=[O:30])=[O:31])[C:13]1=[O:18])#[N:8]

Komponenten

3

Edukt 2

HCID 220172995-Chlorothieno[3,2-b]pyridine-2-sulfonyl chlorideHCID 700880864-hydroxy-3-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-benzonitrile hydrochloride

Produkt 1

HCID 543983155-Chlorothieno[3,2-b]pyridine-2-sulfonic acid [1-(5-cyano-2-hydroxybenzyl)-2-oxo-pyrrolidin-3-(S)-yl]-amide

Versuchsvorschrift

The title compound is prepared from 4-hydroxy-3-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-benzonitrile hydrochloride as described in EXAMPLE 17, Part F using 5-chlorothieno[3,2-b]pyridine-2-sulfonyl chloride in place of 4,6-dichlorobenzo[b]thiophene-2-sulfonyl chloride. The product is obtained as a white solid.

Aufarbeitung

  1. customThe product is obtained as a white solid

Quellen und Nachweise

ORD-Eintrag
ord-7d83168d7ce54c43b52724a182b35f94
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05731315

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