Reaktionsgleichung
Cl.[NH2:2][C:3]1([CH2:8]Cl)[CH2:7][CH2:6][CH2:5][CH2:4]1.[CH3:10][C:11]1[CH:12]=[C:13]([N:20]=[C:21]=[S:22])[CH:14]=[CH:15][C:16]=1[N+:17]([O-:19])=[O:18]>>[CH3:10][C:11]1[CH:12]=[C:13]([N:20]=[C:21]2[S:22][CH2:8][C:3]3([CH2:7][CH2:6][CH2:5][CH2:4]3)[NH:2]2)[CH:14]=[CH:15][C:16]=1[N+:17]([O-:19])=[O:18]Komponenten
3
Versuchsvorschrift
3-Methyl-4-nitroaniline was converted to 3-methyl-4-nitrophenyl isothiocyanate according to Method A2a, Step 3. 1-Amino-1-(hydroxymethyl)cyclopentane was synthesized as described in Method B1c. The 2-hydroxyethylamine was reacted with SOCl2 according to Method B7a to give 1-amino-1-(chloromethyl)cyclopentane HCl salt. The 2-chloroethylamine was reacted with 3-methyl-4-nitrophenyl isothiocyanate according to Method C1a to give 2-(3-methyl-4-nitrophenylimino)-3-thia-1-azaspiro[4.4]nonane. The thiazolidine was reacted with isobutyl bromide according to Method D2a to afford 1-isobutyl-2-(3-methyl-4-nitrophenylimino)-3-thia-1-azaspiro[4.4]nonane.
Quellen und Nachweise
- ORD-Eintrag
- ord-778e83e072ec4d689384ce488a7d6bba
- Quelldatensatz
- uspto-grants-2002_03
- Patentnummer
- US06353006B1
Verknüpfte Notizen
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