Ethanolamine → HCID 178426704, Verbindung

HRID 276701

Reaktionsgleichung

Reaktionsgleichung von HRID 276701
O[CH2:2][C@H:3]([NH2:8])[CH2:4][CH:5]([CH3:7])[CH3:6].COC(=O)[C@@H](CC(C)C)N.OCCN.[CH3:23][C:24]1[CH:29]=[CH:28][C:27]([N+:30]([O-:32])=[O:31])=[CH:26][C:25]=1[N:33]=[C:34]=[S:35]>>[CH3:23][C:24]1[CH:29]=[CH:28][C:27]([N+:30]([O-:32])=[O:31])=[CH:26][C:25]=1[N:33]=[C:34]1[NH:8][C@H:3]([CH2:4][CH:5]([CH3:7])[CH3:6])[CH2:2][S:35]1

Komponenten

5

Edukt 4

HCID 700EthanolamineHCID 89967D-Leucine, methyl esterHCID 2724002D(-)-LeucinolHCID 27599552-Isothiocyanato-1-methyl-4-nitrobenzene

Produkt 1

HCID 178426704HCID 178426704, Verbindung

Versuchsvorschrift

(1R)-1-(Hydroxymethyl)-3-methylbutylamine was made from (D)-leucine methyl ester according to B1b. The 2-hydroxyethylamine was converted to (1R)-1-(chloromethyl)-3-methylbutanammonium chloride as described in Method B7a. 2-Methyl-5-nitrophenyl isothiocyanate was reacted with (1R)-1-(chloromethyl)-3-methylbutanammonium chloride according to Method C1a to give (4R)-2-(2-methyl-5-nitrophenylimino)-4-isobutyl-1,3-thiazolidine. The thiazolidine was reacted with isobutyl bromide according to Method D2a to afford (4R)-2-(N-isobutyl-N-(2-methyl-5-nitrophenyl)amino)-4-isobutyl-1,3-thiazoline HCl salt.

Quellen und Nachweise

ORD-Eintrag
ord-bfe44d4a75de4d2ebbb78a3da7eb652f
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06353006B1

Verknüpfte Notizen

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