N-{1-[(Cyano-dimethyl-methyl)-carbamoyl]-3-methyl-butyl)-4-bromomethyl-benzamide → N-{1-[(Cyano-dimethyl-methyl)-carbamoyl]-3-methyl-butyl}-4-imidazol-1-ylmethyl-benzamide

HRID 276709Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 276709
[C:1]([C:3]([NH:6][C:7]([CH:9]([NH:14][C:15](=[O:24])[C:16]1[CH:21]=[CH:20][C:19]([CH2:22]Br)=[CH:18][CH:17]=1)[CH2:10][CH:11]([CH3:13])[CH3:12])=[O:8])([CH3:5])[CH3:4])#[N:2].[NH:25]1[CH:29]=[CH:28][N:27]=[CH:26]1.[Na]>C1COCC1>[C:1]([C:3]([NH:6][C:7]([CH:9]([NH:14][C:15](=[O:24])[C:16]1[CH:21]=[CH:20][C:19]([CH2:22][N:25]2[CH:29]=[CH:28][N:27]=[CH:26]2)=[CH:18][CH:17]=1)[CH2:10][CH:11]([CH3:13])[CH3:12])=[O:8])([CH3:5])[CH3:4])#[N:2]

Komponenten

4

Edukt 2

HCID 18316679N-{1-[(Cyano-dimethyl-methyl)-carbamoyl]-3-methyl-butyl)-4-bromomethyl-benzamideHCID 57373095Imidazole sodium

Produkt 1

HCID 18316714N-{1-[(Cyano-dimethyl-methyl)-carbamoyl]-3-methyl-butyl}-4-imidazol-1-ylmethyl-benzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

N-{1-[(Cyano-dimethyl-methyl)-carbamoyl]-3-methyl-butyl}-4-bromomethyl-benzamide (0.18 mmol) is dissolved in THF (1 ml) and sodium-imidazol (0.41 mmol) is added and the reaction mixture stirred at RT over night. After evaporation of the solvent, the residue is extracted with ethyl acetate. The extract is washed with water, dried over magnesium sulfate and evaporated. An oil with Rf=0.44 (CH2Cl2/MeOH=9:1) is obtained.

Aufarbeitung

  1. customAfter evaporation of the solvent
  2. extractionthe residue is extracted with ethyl acetate
  3. washThe extract is washed with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated
  6. customAn oil with Rf=0.44 (CH2Cl2/MeOH=9:1) is obtained

Quellen und Nachweise

ORD-Eintrag
ord-e34d418ffe5448dda97e389fde424e4c
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06353017B1

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