1-(4-Chlorophenyl)-2-methylpiperazine → 2-Methyl-1-phenylpiperazine

HRID 276891Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 276891
Cl[C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH:9]2[CH3:14])=[CH:4][CH:3]=1.[H][H]>CO.[C].[Pd]>[C:5]1([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH:9]2[CH3:14])[CH:4]=[CH:3][CH:2]=[CH:7][CH:6]=1

Komponenten

5

Edukt 2

HCID 982891-(4-Chlorophenyl)-2-methylpiperazineHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 980862-Methyl-1-phenylpiperazineAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

1-(4-chlorophenyl)-2-methylpiperazine (300 mg, 1.4 mmol) was dissolved in methanol (3 ml), and the resulting solution was mixed with palladium carbon (150 mg) and stirred at a room temperature for 21 hours in an atmosphere of hydrogen. The reaction solution was filtered, and the thus obtained residue was thoroughly washed with ethanol. The washed solution and filtrate were combined, and the solvent was evaporated therefrom under a reduced pressure to obtain 260 mg of the title compound (1.4 mmol, 100% in yield).

Aufarbeitung

  1. filtrationThe reaction solution was filtered
  2. washthe thus obtained residue was thoroughly washed with ethanol
  3. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-5f1c9b4ff6e7447ebc3163247c5f535a
Quelldatensatz
uspto-grants-2002_03
Patentnummer
US06355642B1

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